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Our Strategy


Anbogen is developing a pipeline of novel therapeutics that harness the power of precision oncology and actional biomarkers to transform life of patients.

With a platform-enabled value proposition in drug development, our strategy is to pursue clinically validated pathways in cancer indications where we identify potential candidate compounds from research institutes, and pursue clinical success through translational research, alliance, co-development, and partnerships to create breakthrough science that meaningfully changes life of patients.

We build our pipeline to address the unmet medical needs from the growing patient population with multiple solid tumor types. Currently there are four proprietary assets that address the unmet medical needs from the growing patient population with multiple solid tumor types We have the potential to pursue both common and rare cancer driven by actional mutation and epigenetic modification and bring the treatments to a wide variety of patients.


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Targets central to well-validated actionable somatic mutations, and epigenetic modification of histone deacetylase inhibition/ immune checkpoint inhibitor combination.

Program



ABT-101, is an oral, tyrosine kinase inhibitor (TKI) for non-small cell lung cancer (NSCLC) patients harboring exon 20 insertions (e20i) in HER2, exon20 kinase domain mutation in other solid tumor cancer types, where there’s currently no available treatment for the patients.

ABT-101 demonstrates excellent therapeutic potential and superior safety profile compared to competitors that are under clinical development. It meets challenges of unmet medical needs for cancer drugs targeting HER2 activating mutations (e20i) in HER2.

KRAS inhibitors, like other targeted therapies, is facing the challenge of drug resistance. To meet the unmet medical needs, Anbogen is developing the second-generation KRAS inhibitors to combat resistance mutations as increasing number of clinical studies have shown that patients using Sotorasib® and Adagrasib® have developed novel drug resistance mutations which lead to the drug resistance.

ABT-202 is a second generation KRAS inhibitor target drug developed by ABT's exclusive covalent combination drug design and structural biology design platform, targeting non-small cell lung cancer and other cancer driver genes (KRAS G12D, G12V).

ABT-301 has demonstrated superior safety in phase 1 study, which opens the possibilities of further clinical development. Data from preclinical studies also show that ABT-301 is highly competitive in treating most solid tumors compared to competing drugs.

ABT-301 is a small molecule histone deacetylase inhibitor (HDACi). Due to the fact that cancer cells exhibit higher histone deacetylase activity, the chromosomal compactness are adjusted to block the expression of certain tumor suppressor genes. The application of such inhibitors will facilitate the expression of tumor suppressor genes, which will help alter the growth, arrest, and differentiation of tumor cells, promote apoptosis, ultimately inhibiting the growth of tumor cells and achieving the treatment of cancer.

Pipeline

Anbogen Pipline
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Our Focus


  1. 1

    Targets central to well-validated actionable somatic mutations, and epigenetic modification of histone deacetylase inhibition.

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    Pursue clincally validated pathways in indications with best-in-class potential

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    Preclinical insights and clincial prove of concept data to drive successful development

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    Anchord in science to transform cancer treatments